HRT users and non-HRT users benefited equally from the exercise

April 22, 2016

Estrogen is known to reduce the chemical imbalances that can lead to cardiovascular diseases such as coronary heart disease and stroke in postmenopausal women. However, recent studies have reported detrimental effects of long-term use of hormone replacement therapy (HRT) or estrogen replacement therapy, including an increased risk of stroke, heart attack and breast cancer. Faced with these potential consequences, more women are turning to exercise as a natural way to combat postmenopausal effect...

Study explains fundamental process of tumor growth

April 21, 2016

Many decades later, this observation was exploited by clinicians to better visualize tumors using PET (positron emission technology) imaging. But it has not been known exactly how tumor cells perform this alternate metabolic feat, nor was it known if this process was essential for tumor growth. Now, two papers appearing in the March 13 issue of the journal Nature help answer these questions. Led by researchers at Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School, the paper...

COX-2 expression is marker for cancer development in some benign breast biopsies

April 20, 2016

This happens to one-fourth of women undergoing breast biopsies but no one knows which individuals are at risk. In their quest to discover who is at risk, researchers at Mayo Clinic are building a biopsy profile to try to predict cancer outcome, and in the March 11 online edition of the Journal of the National Cancer Institute, they report finding a new variable to add to this profile. The research team discovered that women whose atypia tissue expressed COX-2 enzymes were more likely to develo...

Colorectal cancer gene found

April 19, 2016

???Identification of Susceptibility Genes for Cancer in a Genome-wide Scan: Results from the Colon Neoplasia Sibling Study??? is the first large linkage study of families with CRC and colon polyps in the country. Because only five percent of CRC cases are due to known gene defects, this NIH-funded study is designed to identify the remaining CRC-related susceptibility genes. The team built on a previous study which identified a specific region on chromosome 9q that harbors a CRC susceptibility ge...

Risks of long-term hormone therapy continue to outweigh benefits

April 18, 2016

Researchers report that about three years after women stopped taking combination hormone therapy, many of the health effects of hormones such as increased risk of heart disease are diminished, but overall risks, including risks of stroke, blood clots, and cancer, remain high. The WHI is sponsored by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH). Results of the WHI three-year follow-up study of the estrogen-plus-progestin clinical trial are publ...