IV ibuprofen effective in reducing fever in hospitalized patients

April 15, 2016

The study also met its secondary endpoints, as patients receiving the 200 mg dose of IV ibuprofen achieved a 70% reduction in temperature and those receiving the 100 mg dose experienced a 61% reduction. All doses of IV ibuprofen reduced temperatures at 24-hours, and the 400 mg dose was effective in lowering temperature to a normothermic range and maintaining this over 24 hours. There were no significant differences in renal function, bleeding or other serious adverse events between patients receiving IV ibuprofen and those receiving placebo. There were also no significant differences between treatment and placebo groups in terms of adverse event occurrence except for bacteremia (13% in the 100 mg group versus 0% in the placebo group), which was reported by site investigators to be consistent with underlying disease and not related to study drug.

"This data is the latest in a growing body of evidence supporting the safety and efficacy of Caldolor in treating both fever and pain in hospitalized patients," said A.J. Kazimi, Chief Executive Officer of Cumberland Pharmaceuticals. "We are pleased to provide physicians with additional support for Caldolor as a new alternative for reducing fever in hospitalized patients."

Designed primarily for use in the hospital setting, Caldolor is the first FDA approved injectable product for treatment of both pain and fever and is the only intravenous therapy approved for the reduction of fever in the United States.

SOURCE Cumberland Pharmaceuticals Inc.